Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irf9tm1Ttg
Name:	interferon regulatory factor 9; targeted mutation 1, Tadatsugu Taniguchi
MGI ID:	MGI:2446102
Synonyms:	IRF-9-, p48-
Gene:	Irf9  Location: Chr14:55841442-55847487 bp, + strand  Genetic Position: Chr14, 28.19 cM
Alliance:	Irf9tm1Ttg page

Germline Transmission:	Earliest citation of germline transmission: J:77456
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Two exons encoding the DNA binding domain (amino acids 1 through 121) were replaced by a neomycin resistance cassette. Electrophoretic mobility shift assay indicated the loss of Ifna induced activity. (J:77456)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Irf9 Mutation:	40 strains or lines available

Original:	J:77456 Kimura T, et al., Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies. Genes Cells. 1996 Jan;1(1):115-24
All:	42 reference(s)