Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Crkltm1Hkp
Name:	v-crk avian sarcoma virus CT10 oncogene homolog-like; targeted mutation 1, Nora Heisterkamp
MGI ID:	MGI:2446094
Synonyms:	crkl-
Gene:	Crkl  Location: Chr16:17269851-17305298 bp, + strand  Genetic Position: Chr16, 10.82 cM
Alliance:	Crkltm1Hkp page

Germline Transmission:	Earliest citation of germline transmission: J:76680
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. (J:76680)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crkl Mutation:	15 strains or lines available

Original:	J:76680 Hemmeryckx B, et al., BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl. Oncogene. 2002 May 9;21(20):3225-31
All:	2 reference(s)