Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rdh5tm1Wsb
Name:	retinol dehydrogenase 5; targeted mutation 1, William S Blaner
MGI ID:	MGI:2446073
Synonyms:	cRDH-
Gene:	Rdh5  Location: Chr10:128749457-128755906 bp, - strand  Genetic Position: Chr10, 77.19 cM
Alliance:	Rdh5tm1Wsb page

Germline Transmission:	Earliest citation of germline transmission: J:75693
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The majority of exon 2 and all of exon 3 were replaced by a neomycin selection cassette inserted by homologous recombination. The deleted region encoded approximately two thirds of the wild-type protein. While in situ hybridization of homozygous mutant eye sections using a probe for the targeted region indicated an absence of normal transcript, a truncated transcript was identified by Northern blot analysis. (J:75693)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rdh5 Mutation:	11 strains or lines available

Original:	J:75693 Shang E, et al., Targeted disruption of the mouse cis-retinol dehydrogenase gene. Visual and nonvisual functions. J Lipid Res. 2002 Apr;43(4):590-7
All:	1 reference(s)