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Ripk2tm1Ghc
Targeted Allele Detail
Summary
Symbol: Ripk2tm1Ghc
Name: receptor (TNFRSF)-interacting serine-threonine kinase 2; targeted mutation 1, Genhong Cheng
MGI ID: MGI:2446070
Synonyms: Rip2-
Gene: Ripk2  Location: Chr4:16122733-16163647 bp, - strand  Genetic Position: Chr4, 6.7 cM
Alliance: Ripk2tm1Ghc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75401
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis of splenocyte extracts indicated an absence of normal protein in homozygous mutant mice. (J:75401)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ripk2 Mutation:  34 strains or lines available
References
Original:  J:75401 Chin AI, et al., Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature. 2002 Mar 14;416(6877):190-4
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory