Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxdtm5Ddu
Name:	homeobox D cluster; targeted mutation 5, Denis Duboule
MGI ID:	MGI:2445979
Synonyms:	C6cre, L4
Gene:	Hoxd  Location: unknown  Genetic Position: Chr2, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:45706
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Region IX, located in the intergenic region between Hoxd11 and Hoxd10, was disrupted by a 7 nt mutation in a nuclear receptor response element (NRRE). A floxed neo cassette that was included in the targeting construct was removed in vitro via cre mediated recombination, leaving a single loxP site downstream of region IX. (J:45706)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd Mutation:	0 strains or lines available

Original:	J:45706 Gerard M, et al., In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries. Genes Dev. 1996 Sep 15;10(18):2326-34
All:	2 reference(s)