Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Tfcp2tm1Jmc
Name:	transcription factor CP2; targeted mutation 1, John M Cunningham
MGI ID:	MGI:2445840
Gene:	Tfcp2  Location: Chr15:100395893-100449889 bp, - strand  Genetic Position: Chr15, 56.33 cM
Alliance:	Tfcp2tm1Jmc page

Germline Transmission:	Earliest citation of germline transmission: J:67993
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of exon 1 and all of exon 2 was replaced by a hygromycin selection cassette inserted by homologous recombination. The insertion deleted sequence encoding the initiator methionine and the trans-activation domain and introduced a frameshift mutation into all reading frames. Transcript was undetected by both RNAse protection and RT-PCR analysis. (J:67993)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tfcp2 Mutation:	23 strains or lines available

Original:	J:67993 Ramamurthy L, et al., Targeted disruption of the CP2 gene, a member of the NTF family of transcription factors. J Biol Chem. 2001 Mar 16;276(11):7836-42
All:	1 reference(s)