Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ighmtm2.1Che
Name:	immunoglobulin heavy constant mu; targeted mutation 2.1, Jianzhu Chen
MGI ID:	MGI:2445756
Synonyms:	delta mu-s-
Gene:	Ighm  Location: Chr12:113382446-113386350 bp, - strand  Genetic Position: Chr12, 62.1 cM, cytoband F1-2
Alliance:	Ighmtm2.1Che page

Germline Transmission:	Earliest citation of germline transmission: J:59960
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The floxed neo cassette that replaced the endogenous splice donor site was excised from Igh-6tm2Che via in vivo cre mediated recombination. No transcript was detected by Northern blot analysis of homozygous mutant mice. (J:59960)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ighm Mutation:	55 strains or lines available

Original:	J:59960 Kuzin II, et al., Normal isotype switching in B cells lacking the I mu exon splice donor site: evidence for multiple I mu-like germline transcripts. J Immunol. 2000 Feb 1;164(3):1451-7
All:	1 reference(s)