Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gja1tm1.1Kwi
Name:	gap junction protein, alpha 1; targeted mutation 1., Klaus Willecke
MGI ID:	MGI:2445472
Synonyms:	Cx43del
Gene:	Gja1  Location: Chr10:56253297-56266519 bp, + strand  Genetic Position: Chr10, 28.64 cM
Alliance:	Gja1tm1.1Kwi page

Germline Transmission:	Earliest citation of germline transmission: J:78662
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region contained within loxP sites flanking exon 2 and the floxed tk-neo cassette were removed by mating Gja1tm1Kwi animals to cre deleter strain TgN(CMV-cre)1Cgn. Resulting progeny retained a single loxP site and lacZ cassette. (J:78662)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gja1 Mutation:	59 strains or lines available

Original:	J:78662 Theis M, et al., Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis. 2001 Jan;29(1):1-13
All:	16 reference(s)