Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Xisttm2.1Jae
Name:	inactive X specific transcripts; targeted mutation 2.1, Rudolf Jaenisch
MGI ID:	MGI:2445460
Synonyms:	deltaXist, Xist1lox
Gene:	Xist  Location: ChrX:102503979-102526839 bp, - strand  Genetic Position: ChrX, 46.15 cM, cytoband D
Alliance:	Xisttm2.1Jae page

Germline Transmission:	Earliest citation of germline transmission: J:80117
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 1, 2, and 3 as well as 5 kb of the proximal promoter were deleted via cre mediated recombination of single loxP sites in the 5' untranslated region and intron 3. Though complete transcriptional ablation was previously reported by Csankocszki et al., 1999 (J:75502), Turner et al., 2002 (J:80117) reported an endogenous testis-specific transcript that utilizes an upstream promoter in wild-type mice and therefore is putatively present in mutant mice. The deleted region encoded a domain essential for X chromosome inactivation. (J:75502, J:80117)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xist Mutation:	8 strains or lines available

Original:	J:80117 Turner JM, et al., Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist. J Cell Sci. 2002 Nov 1;115(Pt 21):4097-105
All:	7 reference(s)