Socs1tm1Kish
Targeted Allele Detail
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| Symbol: |
Socs1tm1Kish |
| Name: |
suppressor of cytokine signaling 1; targeted mutation 1, Tadamitsu Kishimoto |
| MGI ID: |
MGI:2445448 |
| Synonyms: |
SSI-1- |
| Gene: |
Socs1 Location: Chr16:10601672-10603400 bp, - strand Genetic Position: Chr16, 5.81 cM
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| Alliance: |
Socs1tm1Kish page
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Histological appearances of the spleen and thymus in Socs1tm1Kish/Socs1tm1Kish mice
Show the 1 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:51685
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A large portion of exon 2 (approximately 0.6 kb of genomic sequence) was replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of lung tissue RNA confirmed the absence of gene expression in homozygous mutant animals.
(J:51685)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Socs1 Mutation: |
29 strains or lines available
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| Original: |
J:51685 Naka T, et al., Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15577-82 |
| All: |
11 reference(s) |
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Analysis Tools
