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Ppargc1b Gene Detail
Summary
  • Symbol
    Ppargc1b
  • Name
    peroxisome proliferative activated receptor, gamma, coactivator 1 beta
  • Synonyms
    4631412G21Rik, PGC-1beta/ERRL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444934
    NCBI Gene: 170826
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:61431207-61533502 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.41 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    971 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444934
 protein coding gene Chr18:61424516-61533846 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024479
 protein coding gene Chr18:61181971-61283861 (-)
A/J MGP_AJ_G0024446
 protein coding gene Chr18:58548370-58651301 (-)
AKR/J MGP_AKRJ_G0024416
 protein coding gene Chr18:60162926-60266543 (-)
BALB/cJ MGP_BALBcJ_G0024445
 protein coding gene Chr18:58676709-58779260 (-)
C3H/HeJ MGP_C3HHeJ_G0024213
 protein coding gene Chr18:60388982-60499453 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024892
 protein coding gene Chr18:62831623-62948640 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022323
 protein coding gene Chr18:58092887-58196087 (-)
CAST/EiJ MGP_CASTEiJ_G0023686
 protein coding gene Chr18:60261402-60373747 (-)
CBA/J MGP_CBAJ_G0024183
 protein coding gene Chr18:64845650-64965860 (-)
DBA/2J MGP_DBA2J_G0024313
 protein coding gene Chr18:58215233-58318007 (-)
FVB/NJ MGP_FVBNJ_G0024279
 protein coding gene Chr18:57627979-57730666 (-)
LP/J MGP_LPJ_G0024396
 protein coding gene Chr18:61020531-61139456 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024308
 protein coding gene Chr18:66462784-66574620 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024939
 protein coding gene Chr18:60350750-60463482 (-)
PWK/PhJ MGP_PWKPhJ_G0023429
 protein coding gene Chr18:58445788-58550687 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023235
 protein coding gene Chr18:60589955-60695231 (-)
WSB/EiJ MGP_WSBEiJ_G0023750
 protein coding gene Chr18:60217060-60328394 (-)



Homology
more
  • Human Ortholog
    PPARGC1B, PPARG coactivator 1 beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPARGC1B, PPARG coactivator 1 beta
  • Synonyms
    ERRL1, PERC, PGC1B, PGC-1(beta)
  • Links
    NCBI Gene ID: 133522
    neXtProt AC: NX_Q86YN6
    UniProt: Q86YN6

  • Chr Location
    5q32; chr5:149730298-149857959 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PPARGC1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 7 alleles in 7 genetic backgrounds
    20 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene can lead to postnatal lethality and impaired mitochondrial activity, adaptive thermogenesis, and hepatic function. Homozygotes for a null allele also display a defect in heart rate regulation, reduced body weight and WAT content, and increased energy expenditure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    33
  • cDNA Data
    24
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033871 Ensembl Gene Model | MGI Sequence Detail 102296 C57BL/6J ±  kb
    transcript ENSMUST00000063307 Ensembl | MGI Sequence Detail 3330 Not Applicable  
    polypeptide ENSMUSP00000069431 Ensembl | MGI Sequence Detail 1030 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 24
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 19
      Gene Ontology 11
      Phenotypes 53
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:344389 Abe Y, et al., A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2316104121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory