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Apol8 Gene Detail
Summary
  • Symbol
    Apol8
  • Name
    apolipoprotein L 8
  • Synonyms
    9830006J20Rik, Apol2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444921
    NCBI Gene: 239552
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:77631998-77641203 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 36.79 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444921
 protein coding gene Chr15:77629309-77641306 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022030
 protein coding gene Chr15:77873902-77881324 (-)
A/J MGP_AJ_G0021990
 protein coding gene Chr15:75181686-75189104 (-)
AKR/J MGP_AKRJ_G0021967
 protein coding gene Chr15:77259866-77267296 (-)
BALB/cJ MGP_BALBcJ_G0021998
 protein coding gene Chr15:75193063-75200487 (-)
C3H/HeJ MGP_C3HHeJ_G0021769
 protein coding gene Chr15:77339434-77346854 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022440
 protein coding gene Chr15:80949181-80956607 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019969
 protein coding gene Chr15:71756271-71764636 (-)
CAST/EiJ MGP_CASTEiJ_G0021289
 protein coding gene Chr15:77918325-77925752 (-)
CBA/J MGP_CBAJ_G0021734
 protein coding gene Chr15:83441012-83448430 (-)
DBA/2J MGP_DBA2J_G0021862
 protein coding gene Chr15:74676803-74684197 (-)
FVB/NJ MGP_FVBNJ_G0021841
 protein coding gene Chr15:73669273-73676683 (-)
LP/J MGP_LPJ_G0021931
 protein coding gene Chr15:78063946-78071406 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021861
 protein coding gene Chr15:88650796-88658975 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022454
 protein coding gene Chr15:77336743-77349667 (-)
PWK/PhJ MGP_PWKPhJ_G0021031
 protein coding gene Chr15:74657607-74665079 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020867
 protein coding gene Chr15:77112343-77120854 (-)
WSB/EiJ MGP_WSBEiJ_G0021342
 protein coding gene Chr15:77655855-77669893 (-)



Homology
more
  • Human Ortholog
    APOL1, apolipoprotein L1
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOL1, apolipoprotein L1
  • Synonyms
    APOL, APO-L, APOL-I, FSGS4
  • Links
    NCBI Gene ID: 8542
    neXtProt AC: NX_O14791
    UniProt: O14791

  • Chr Location
    22q12.3; chr22:36253071-36267530 (+)  GRCh38
  • Human Ortholog
    APOL2, apolipoprotein L2
  • Synonyms
    APOL3, APOL-II
  • Links
    NCBI Gene ID: 23780
    neXtProt AC: NX_Q9BQE5
    UniProt: Q9BQE5

  • Chr Location
    22q12.3; chr22:36226209-36239954 (-)  GRCh38
  • Human Ortholog
    APOL3, apolipoprotein L3
  • Synonyms
    apoL-III, APOLIII, CG121, CG12_1
  • Links
    NCBI Gene ID: 80833
    neXtProt AC: NX_O95236
    UniProt: O95236

  • Chr Location
    22q12.3; chr22:36140323-36166177 (-)  GRCh38
  • Human Ortholog
    APOL4, apolipoprotein L4
  • Synonyms
    APOLIV, APOL-IV
  • Links
    NCBI Gene ID: 80832
    neXtProt AC: NX_Q9BPW4
    UniProt: Q9BPW4

  • Chr Location
    22q12.3; chr22:36189124-36204840 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human APOL2,APOL4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    1
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056656 Ensembl Gene Model | MGI Sequence Detail 9206 C57BL/6J ±  kb
transcript ENSMUST00000070911 Ensembl | MGI Sequence Detail 2801 Not Applicable  
polypeptide ENSMUSP00000064237 Ensembl | MGI Sequence Detail 339 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR008405 Apolipoprotein L
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 44
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 2
    Phenotypes 25
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory