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Tbc1d25 Gene Detail
Summary
  • Symbol
    Tbc1d25
  • Name
    TBC1 domain family, member 25
  • Synonyms
    6330576A08Rik, DXHXS7927e, mMg81, Oatl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444862
    NCBI Gene: 209815
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:8020711-8042420 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444862
protein coding gene ChrX:8020709-8042420 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035542
protein coding gene ChrX:2801974-2825268 (-)
A/J MGP_AJ_G0035519
protein coding gene ChrX:2776254-2799735 (-)
AKR/J MGP_AKRJ_G0035452
protein coding gene ChrX:2892727-2915120 (-)
BALB/cJ MGP_BALBcJ_G0035516
protein coding gene ChrX:2774496-2796455 (-)
C3H/HeJ MGP_C3HHeJ_G0035224
protein coding gene ChrX:2858996-2882221 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036040
protein coding gene ChrX:2896218-2919830 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032915
protein coding gene ChrX:2301433-2324334 (-)
CAST/EiJ MGP_CASTEiJ_G0034525
protein coding gene ChrX:2745284-2767506 (-)
CBA/J MGP_CBAJ_G0035194
protein coding gene ChrX:3048012-3074069 (-)
DBA/2J MGP_DBA2J_G0035351
protein coding gene ChrX:2762227-2784103 (-)
FVB/NJ MGP_FVBNJ_G0035298
protein coding gene ChrX:2728458-2750843 (-)
LP/J MGP_LPJ_G0035428
protein coding gene ChrX:2822343-2843219 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035338
protein coding gene ChrX:2996503-3018223 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036058
protein coding gene ChrX:2783066-2804622 (-)
PWK/PhJ MGP_PWKPhJ_G0034225
protein coding gene ChrX:2704411-2726795 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034064
protein coding gene ChrX:2761648-2782866 (-)
WSB/EiJ MGP_WSBEiJ_G0034648
protein coding gene ChrX:2787155-2809341 (-)



Homology
more
  • Human Ortholog
    TBC1D25, TBC1 domain family member 25
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBC1D25, TBC1 domain family member 25
  • Synonyms
    MG81, OATL1
  • Links
    NCBI Gene ID: 4943
    neXtProt AC: NX_Q3MII6
    UniProt: Q3MII6

  • Chr Location
    Xp11.23; chrX:48539714-48562609 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele show exacerbated cardiac hypertrophy, fibrosis and dysfunction in response to partial transverse aortic constriction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039201 Ensembl Gene Model | MGI Sequence Detail 21710 C57BL/6J ±  kb
    transcript ENSMUST00000039892 Ensembl | MGI Sequence Detail 2648 Not Applicable  
    polypeptide ENSMUSP00000047838 Ensembl | MGI Sequence Detail 742 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 2
      cDNA 31
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1099472
    References
    more
    • Summaries
      All 37
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:55860 Derry JM, et al., Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com. Nat Genet. 1999 Jul;22(3):286-90
    • Latest
      J:331167 Zhang Z, et al., TBC1Domain Family Member 25 deficiency aggravates cerebral ischemia-reperfusion injury via TAK1-JNK/p38 pathway. J Neurochem. 2022 Feb;160(3):392-411

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory