Fcgbp MGI Mouse Gene Detail - MGI:2444336 - Fc fragment of IgG binding protein

Symbol

Fcgbp
Name

Fc fragment of IgG binding protein
Synonyms

A430096B05Rik

Feature Type

protein coding gene
IDs

MGI:2444336
NCBI Gene: 215384
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr7:27770661-27820287 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.26 cM

SNPs within 2kb

336 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444336	protein coding gene	Chr7:27770661-27820289 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031929	protein coding gene	Chr7:26828975-26877068 (+)
A/J	MGP_AJ_G0031908	protein coding gene	Chr7:26161735-26218876 (+)
AKR/J	MGP_AKRJ_G0031839	protein coding gene	Chr7:26847438-26902564 (+)
BALB/cJ	MGP_BALBcJ_G0031914	protein coding gene	Chr7:26336283-26382876 (+)
C3H/HeJ	MGP_C3HHeJ_G0031636	protein coding gene	Chr7:27209014-27258306 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032379	protein coding gene	Chr7:27683755-27744882 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029431	protein coding gene	Chr7:27298602-27336396 (+)
CAST/EiJ	MGP_CASTEiJ_G0030971	protein coding gene	Chr7:20536126-20576001 (+)
CBA/J	MGP_CBAJ_G0031599	protein coding gene	Chr7:28914685-28976150 (+)
DBA/2J	MGP_DBA2J_G0031752	protein coding gene	Chr7:25945069-25997433 (+)
FVB/NJ	MGP_FVBNJ_G0031709	protein coding gene	Chr7:26033844-26071325 (+)
LP/J	MGP_LPJ_G0031833	protein coding gene	Chr7:27144900-27199371 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031744	protein coding gene	Chr7:28449369-28509181 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032409	protein coding gene	Chr7:26314195-26366029 (+)
PWK/PhJ	MGP_PWKPhJ_G0030694	protein coding gene	Chr7:20955800-21002530 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030529	protein coding gene	Chr7:17332455-17343693 (+)
WSB/EiJ	MGP_WSBEiJ_G0031078	protein coding gene	Chr7:26666570-26709842 (+)

Human Ortholog

FCGBP, Fc gamma binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FCGBP, Fc gamma binding protein
Synonyms

FC(GAMMA)BP
Links

HGNC:13572

NCBI Gene ID: 8857

neXtProt AC: NX_Q9Y6R7

UniProt: Q9Y6R7
Chr Location

19q13.2; chr19:39863323-39934634 (-) GRCh38

MGI Vertebrate Homology

Fcgbp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FCGBP
Gene Tree

Fcgbp

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

121 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

10
cDNA Data

231
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fcgbp

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All Sequences

64
RefSeq

2
UniProt

12
CCDS

CCDS52159.1

Ensembl

ENSMUSG00000047730 (Evidence)
NCBI Gene

215384

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047730	Ensembl Gene Model \| MGI Sequence Detail	49627	C57BL/6J	± kb
transcript	ENSMUST00000138392	Ensembl \| MGI Sequence Detail	7926	Not Applicable
polypeptide	ENSMUSP00000114271	Ensembl \| MGI Sequence Detail	2583	Not Applicable

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UniProt

12 Sequences
InterPro Domains

IPR003645 Follistatin-like, N-terminal

IPR036084 Serine protease inhibitor-like superfamily

IPR036773 TGF-beta binding (TB) domain superfamily

IPR025615 TILa domain

IPR002919 Trypsin Inhibitor-like, cysteine rich domain

IPR001846 von Willebrand factor, type D domain

IPR001007 VWFC domain

IPR014853 VWF/SSPO/Zonadhesin-like, cysteine-rich domain

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All nucleic 231

cDNA 231

Microarray probesets 3

Summaries

All 32

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 10
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:307299 Ehrencrona E, et al., The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds. J Biol Chem. 2021 Jun 11;297(1):100871

TSS for Fcgbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65341	Chr7:27770370-27770374 (+)	-289 bp
Tssr65342	Chr7:27770423-27770454 (+)	-222 bp
Tssr65343	Chr7:27770623-27770638 (+)	-30 bp
Tssr65344	Chr7:27770640-27770653 (+)	-14 bp
Tssr65345	Chr7:27770655-27770667 (+)	0 bp
Tssr65346	Chr7:27774602-27774613 (+)	3,947 bp
Tssr65347	Chr7:27774629-27774640 (+)	3,974 bp
Tssr65348	Chr7:27774649-27774667 (+)	3,997 bp
Tssr65349	Chr7:27774720-27774727 (+)	4,063 bp
Tssr65350	Chr7:27774736-27774753 (+)	4,084 bp
Tssr65351	Chr7:27774758-27774775 (+)	4,106 bp
Tssr65352	Chr7:27784342-27784375 (+)	13,698 bp
Tssr65353	Chr7:27784616-27784637 (+)	13,966 bp
Tssr2155	Chr7:27784779-27784790 (+)	14,124 bp
Tssr65354	Chr7:27784838-27784849 (+)	14,183 bp
Tssr65355	Chr7:27785758-27785767 (+)	15,102 bp
Tssr65356	Chr7:27785771-27785786 (+)	15,118 bp
Tssr65357	Chr7:27785895-27785905 (+)	15,239 bp
Tssr65358	Chr7:27785950-27785968 (+)	15,298 bp
Tssr65359	Chr7:27789237-27789252 (+)	18,584 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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