Tnrc6b MGI Mouse Gene Detail - MGI:2443730 - trinucleotide repeat containing 6b

Symbol

Tnrc6b
Name

trinucleotide repeat containing 6b
Synonyms

2700090M07Rik, A730065C02Rik, D230019K20Rik, mKIAA1093

Feature Type

protein coding gene
IDs

MGI:2443730
NCBI Gene: 213988
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr15:80595514-80825286 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.91 cM
Mapping Data

2 experiments

SNPs within 2kb

729 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443730	protein coding gene	Chr15:80595514-80825287 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022103	protein coding gene	Chr15:81080750-81331540 (+)
A/J	MGP_AJ_G0022064	protein coding gene	Chr15:78249994-78487289 (+)
AKR/J	MGP_AKRJ_G0022039	protein coding gene	Chr15:80441526-80682545 (+)
BALB/cJ	MGP_BALBcJ_G0022070	protein coding gene	Chr15:78258692-78492707 (+)
C3H/HeJ	MGP_C3HHeJ_G0021841	protein coding gene	Chr15:80429956-80666367 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022513	protein coding gene	Chr15:84265848-84515486 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020043	protein coding gene	Chr15:74735667-74963978 (+)
CAST/EiJ	MGP_CASTEiJ_G0021362	protein coding gene	Chr15:81164366-81409836 (+)
CBA/J	MGP_CBAJ_G0021806	protein coding gene	Chr15:86914455-87160923 (+)
DBA/2J	MGP_DBA2J_G0021935	protein coding gene	Chr15:77745769-77976668 (+)
FVB/NJ	MGP_FVBNJ_G0021913	protein coding gene	Chr15:76779146-77011201 (+)
LP/J	MGP_LPJ_G0022003	protein coding gene	Chr15:81251706-81496716 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021933	protein coding gene	Chr15:91918187-92157166 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022527	protein coding gene	Chr15:80485016-80725796 (+)
PWK/PhJ	MGP_PWKPhJ_G0021104	protein coding gene	Chr15:77757080-77992734 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020941	protein coding gene	Chr15:80284158-80521630 (+)
WSB/EiJ	MGP_WSBEiJ_G0021414	protein coding gene	Chr15:80892660-81131526 (+)

Human Ortholog

TNRC6B, trinucleotide repeat containing adaptor 6B

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNRC6B, trinucleotide repeat containing adaptor 6B
Synonyms

GDSBA
Links

HGNC:29190

NCBI Gene ID: 23112

neXtProt AC: NX_Q9UPQ9

UniProt: Q9UPQ9
Chr Location

22q13.1; chr22:40044817-40335808 (+) GRCh38

MGI Vertebrate Homology

Tnrc6b stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: TNRC6B
Gene Tree

Tnrc6b

Diseases

2 with human TNRC6B associations

				Human Disease	Mouse Models
				subserous uterine fibroid IDs subserous uterine fibroid DOID:13560 ICD10CM:D25.2 ICD9CM:218.2 UMLS_CUI:C0153995
				uterine fibroid IDs uterine fibroid DOID:13223 EFO:0000731 ICD10CM:D25 ICD9CM_2006:218 ICD9CM:218 ICD9CM:218.9 MESH:D007889 NCI:C3434 OMIM:150699 UMLS_CUI:C0042133

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

125
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

114
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Tnrc6b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

130 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit neonatal and postnatal lethality with decreased body weight and infertility.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

1
cDNA Data

19
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tnrc6b

ZFIN tnrc6ba

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All Sequences

78
RefSeq

4
UniProt

14
CCDS

CCDS37146.1

Ensembl

ENSMUSG00000047888 (Evidence)
NCBI Gene

213988

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047888	Ensembl Gene Model \| MGI Sequence Detail	229773	C57BL/6J	± kb
transcript	ENSMUST00000067689	Ensembl \| MGI Sequence Detail	17332	Not Applicable
polypeptide	ENSMUSP00000064336	Ensembl \| MGI Sequence Detail	1810	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000016519 trinucleotide repeat-containing gene 6B protein

(term hierarchy)
InterPro Domains

IPR019486 Argonaute hook domain

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR034925 TNRC6B, RNA recognition motif

IPR032226 TNRC6, PABC binding domain

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 4

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MGI:1919875, MGI:2146082, MGI:2442182

Summaries

All 65

Developmental Gene Expression 3

Diseases 1

Gene Ontology 5

Phenotypes 37
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Tnrc6b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132238	Chr15:80595442-80595466 (+)	-60 bp
Tssr132239	Chr15:80595493-80595541 (+)	3 bp
Tssr132240	Chr15:80606719-80606723 (+)	11,207 bp
Tssr132241	Chr15:80627994-80628039 (+)	32,503 bp
Tssr132242	Chr15:80646625-80646658 (+)	51,128 bp
Tssr132243	Chr15:80682787-80682809 (+)	87,284 bp
Tssr132244	Chr15:80682828-80682853 (+)	87,327 bp
Tssr132245	Chr15:80704604-80704616 (+)	109,096 bp
Tssr132246	Chr15:80704623-80704635 (+)	109,115 bp
Tssr132247	Chr15:80781394-80781399 (+)	185,883 bp
Tssr132248	Chr15:80786593-80786608 (+)	191,087 bp
Tssr132249	Chr15:80814718-80814728 (+)	219,209 bp
Tssr132250	Chr15:80814732-80814755 (+)	219,230 bp
Tssr132251	Chr15:80815489-80815523 (+)	219,992 bp
Tssr132252	Chr15:80821323-80821348 (+)	225,822 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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