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Pik3r5 Gene Detail
Summary
  • Symbol
    Pik3r5
  • Name
    phosphoinositide-3-kinase regulatory subunit 5
  • Synonyms
    Foap2, p101
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443588
    NCBI Gene: 320207
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:68322951-68388675 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 41.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    347 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443588
 protein coding gene Chr11:68322947-68388675 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018500
 protein coding gene Chr11:68778785-68845584 (+)
A/J MGP_AJ_G0018469
 protein coding gene Chr11:66208250-66274515 (+)
AKR/J MGP_AKRJ_G0018438
 protein coding gene Chr11:68178214-68245770 (+)
BALB/cJ MGP_BALBcJ_G0018440
 protein coding gene Chr11:66496655-66562504 (+)
C3H/HeJ MGP_C3HHeJ_G0018253
 protein coding gene Chr11:68204101-68269716 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018892
 protein coding gene Chr11:70877686-70946136 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016536
 protein coding gene Chr11:63147878-63213708 (+)
CAST/EiJ MGP_CASTEiJ_G0017809
 protein coding gene Chr11:68435083-68506434 (+)
CBA/J MGP_CBAJ_G0018227
 protein coding gene Chr11:74017663-74086347 (+)
DBA/2J MGP_DBA2J_G0018336
 protein coding gene Chr11:65808696-65874372 (+)
FVB/NJ MGP_FVBNJ_G0018326
 protein coding gene Chr11:65429383-65496842 (+)
LP/J MGP_LPJ_G0018407
 protein coding gene Chr11:69352182-69418811 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018349
 protein coding gene Chr11:74734392-74801411 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018933
 protein coding gene Chr11:68427316-68494874 (+)
PWK/PhJ MGP_PWKPhJ_G0017584
 protein coding gene Chr11:66431165-66497784 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017372
 protein coding gene Chr11:68271183-68336458 (+)
WSB/EiJ MGP_WSBEiJ_G0017862
 protein coding gene Chr11:68053430-68122741 (+)



Homology
more
  • Human Ortholog
    PIK3R5, phosphoinositide-3-kinase regulatory subunit 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3R5, phosphoinositide-3-kinase regulatory subunit 5
  • Synonyms
    F730038I15Rik, FOAP-2, p101, P101-PI3K
  • Links
    NCBI Gene ID: 23533
    neXtProt AC: NX_Q8WYR1
    UniProt: Q8WYR1

  • Chr Location
    17p13.1; chr17:8878911-8965712 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PIK3R5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit significantly reduced neutrophil chemotaxis and chemokinesis in vitro and impaired neutrophil recruitment into the peritoneum in a model of thioglycollate-induced aseptic peritonitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    24
  • cDNA Data
    31
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 320207 NCBI Gene Model | MGI Sequence Detail 65725 C57BL/6J ±  kb
transcript NM_177320 RefSeq | MGI Sequence Detail 4363 C57BL/6  
polypeptide Q5SW28 UniProt | EBI | MGI Sequence Detail 871 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012728 phosphoinositide 3-kinase regulatory subunit 5
    (term hierarchy)
  • InterPro Domains
    IPR019522 Phosphoinositide 3-kinase regulatory subunit 5/6
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144465
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:342280 Rynkiewicz NK, et al., Gbetagamma is a direct regulator of endogenous p101/p110gamma and p84/p110gamma PI3Kgamma complexes in mouse neutrophils. Sci Signal. 2020 Nov 3;13(656)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory