About   Help   FAQ
Relt Gene Detail
Summary
  • Symbol
    Relt
  • Name
    RELT tumor necrosis factor receptor
  • Synonyms
    E430021K24Rik, Tnfrsf19l
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443373
    NCBI Gene: 320100
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100495054-100512653 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443373
 protein coding gene Chr7:100495054-100512690 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032577
 protein coding gene Chr7:103766640-103783497 (-)
A/J MGP_AJ_G0032551
 protein coding gene Chr7:101137603-101154476 (-)
AKR/J MGP_AKRJ_G0032487
 protein coding gene Chr7:103544930-103563541 (-)
BALB/cJ MGP_BALBcJ_G0032562
 protein coding gene Chr7:100825317-100842214 (-)
C3H/HeJ MGP_C3HHeJ_G0032277
 protein coding gene Chr7:103936246-103957282 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033060
 protein coding gene Chr7:107694493-107712085 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030054
 protein coding gene Chr7:103526268-103543237 (-)
CAST/EiJ MGP_CASTEiJ_G0031604
 protein coding gene Chr7:95491448-95512232 (-)
CBA/J MGP_CBAJ_G0032244
 protein coding gene Chr7:111411048-111430963 (-)
DBA/2J MGP_DBA2J_G0032395
 protein coding gene Chr7:99467305-99485204 (-)
FVB/NJ MGP_FVBNJ_G0032352
 protein coding gene Chr7:99253534-99271630 (-)
LP/J MGP_LPJ_G0032485
 protein coding gene Chr7:105103244-105119971 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032385
 protein coding gene Chr7:112788914-112807072 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033082
 protein coding gene Chr7:102804760-102824874 (-)
PWK/PhJ MGP_PWKPhJ_G0031322
 protein coding gene Chr7:92584424-92605319 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031165
 protein coding gene Chr7:90122454-90139670 (-)
WSB/EiJ MGP_WSBEiJ_G0031721
 protein coding gene Chr7:103511043-103533863 (-)



Homology
more
  • Human Ortholog
    RELT, RELT TNF receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RELT, RELT TNF receptor
  • Synonyms
    AI3C, TNFRSF19L, TRLT
  • Links
    NCBI Gene ID: 84957
    neXtProt AC: NX_Q969Z4
    UniProt: Q969Z4

  • Chr Location
    11q13.4; chr11:73376399-73397474 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Relt mouse models; 1 with human RELT associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with a premature termination codon resulting in a null allele exhibit incisor and molar enamel malformations. Homozygous knockout affects T cell proliferation and reduces tumor growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    19
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008318 Ensembl Gene Model | MGI Sequence Detail 17600 C57BL/6J ±  kb
    transcript ENSMUST00000008462 Ensembl | MGI Sequence Detail 2851 Not Applicable  
    polypeptide ENSMUSP00000008462 Ensembl | MGI Sequence Detail 436 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013880 tumor necrosis factor receptor superfamily member 19L
      (term hierarchy)
    • InterPro Domains
      IPR022248 TNF receptor family, RELT
      IPR001368 TNFR/NGFR cysteine-rich region
      IPR034048 Tumor necrosis factor receptor 19-like, N-terminal
      IPR022333 Tumour necrosis factor receptor 19-like
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 3
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:279949 Kim JW, et al., Mutations in RELT cause autosomal recessive amelogenesis imperfecta. Clin Genet. 2019 Mar;95(3):375-383
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory