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Tnni3k Gene Detail
Summary
  • Symbol
    Tnni3k
  • Name
    TNNI3 interacting kinase
  • Synonyms
    Cark, D830019J24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443276
    NCBI Gene: 435766
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:154491928-154761044 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 79.32 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1771 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443276
 protein coding gene Chr3:154491928-154761044 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028006
 protein coding gene Chr3:158814352-159086482 (-)
A/J MGP_AJ_G0027965
 protein coding gene Chr3:153011613-153291433 (-)
AKR/J MGP_AKRJ_G0027931
 protein coding gene Chr3:157104662-157385039 (-)
BALB/cJ MGP_BALBcJ_G0027977
 protein coding gene Chr3:152820924-153091304 (-)
C3H/HeJ MGP_C3HHeJ_G0027707
 protein coding gene Chr3:157471553-157755838 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028420
 protein coding gene Chr3:163982521-164268488 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025758
 protein coding gene Chr3:147764950-148024603 (-)
CAST/EiJ MGP_CASTEiJ_G0027160
 protein coding gene Chr3:157605864-157888830 (-)
CBA/J MGP_CBAJ_G0027682
 protein coding gene Chr3:169885770-170173029 (-)
DBA/2J MGP_DBA2J_G0027822
 protein coding gene Chr3:152083549-152352304 (-)
FVB/NJ MGP_FVBNJ_G0027789
 protein coding gene Chr3:149459913-149727466 (-)
LP/J MGP_LPJ_G0027933
 protein coding gene Chr3:160132472-160410220 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027822
 protein coding gene Chr3:178316012-178596458 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028479
 protein coding gene Chr3:156747786-157024558 (-)
PWK/PhJ MGP_PWKPhJ_G0026883
 protein coding gene Chr3:152018428-152290721 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026711
 protein coding gene Chr3:154918544-155213188 (-)
WSB/EiJ MGP_WSBEiJ_G0027240
 protein coding gene Chr3:157738421-158007085 (-)



Homology
more
  • Human Ortholog
    FPGT-TNNI3K, FPGT-TNNI3K readthrough
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FPGT-TNNI3K, FPGT-TNNI3K readthrough
  • Synonyms
    CARK, TNNI3K
  • Links
    NCBI Gene ID: 100526835
    neXtProt AC: NX_Q59H18

  • Chr Location
    1p31.1; chr1:74198235-74544428 (+)  GRCh38
  • Human Ortholog
    TNNI3K, TNNI3 interacting kinase
  • Synonyms
    CARK, CCDD
  • Links
    NCBI Gene ID: 51086
    neXtProt AC: NX_Q59H18
    UniProt: Q59H18

  • Chr Location
    1p31.1; chr1:74235387-74544428 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in cardiac myocytes exhibit decreased response to cardiac ischemic/reperfusion injury. A strain-specific splicing allele (knockout) is protective against specific induced cardiopathies but has a negative effect on some heart parameters and on glucose metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 435766 NCBI Gene Model | MGI Sequence Detail 269117 C57BL/6J ±  kb
    transcript NM_177066 RefSeq | MGI Sequence Detail 3042 C57BL/6  
    polypeptide Q5GIG6 UniProt | EBI | MGI Sequence Detail 834 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 42
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:339970 Purdy AL, et al., Tnni3k influences cardiomyocyte S-phase activity and proliferation. J Mol Cell Cardiol. 2023 Aug 17;183:22-26
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory