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Mylk3 Gene Detail
Summary
  • Symbol
    Mylk3
  • Name
    myosin light chain kinase 3
  • Synonyms
    D830007F02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443063
    NCBI Gene: 213435
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:86050933-86112969 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    883 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443063
 protein coding gene Chr8:86050932-86112974 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033900
 protein coding gene Chr8:86250135-86312884 (-)
A/J MGP_AJ_G0033883
 protein coding gene Chr8:82849932-82908408 (-)
AKR/J MGP_AKRJ_G0033809
 protein coding gene Chr8:85312258-85372674 (-)
BALB/cJ MGP_BALBcJ_G0033876
 protein coding gene Chr8:82990153-83052343 (-)
C3H/HeJ MGP_C3HHeJ_G0033587
 protein coding gene Chr8:85944808-86008457 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034397
 protein coding gene Chr8:89595545-89653380 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031337
 protein coding gene Chr8:76641224-76702845 (-)
CAST/EiJ MGP_CASTEiJ_G0032916
 protein coding gene Chr8:85363515-85424497 (-)
CBA/J MGP_CBAJ_G0033562
 protein coding gene Chr8:92602930-92671131 (-)
DBA/2J MGP_DBA2J_G0033715
 protein coding gene Chr8:82495372-82559429 (-)
FVB/NJ MGP_FVBNJ_G0033663
 protein coding gene Chr8:81441618-81501979 (-)
LP/J MGP_LPJ_G0033807
 protein coding gene Chr8:86363012-86430339 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033706
 protein coding gene Chr8:95155310-95223085 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034414
 protein coding gene Chr8:85320276-85376127 (-)
PWK/PhJ MGP_PWKPhJ_G0032620
 protein coding gene Chr8:81740876-81801305 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032456
 protein coding gene Chr8:84113829-84171394 (-)
WSB/EiJ MGP_WSBEiJ_G0033029
 protein coding gene Chr8:85737766-85798296 (-)



Homology
more
  • Human Ortholog
    MYLK3, myosin light chain kinase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYLK3, myosin light chain kinase 3
  • Synonyms
    caMLCK, MLCK, MLCK2
  • Links
    NCBI Gene ID: 91807
    neXtProt AC: NX_Q32MK0
    UniProt: Q32MK0

  • Chr Location
    16q11.2; chr16:46702282-46790407 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 4 alleles in 3 genetic backgrounds
    1 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit cardiac hypertrophy, reduced cardiac function and increased response of heart to induced stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    4
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 213435 NCBI Gene Model | MGI Sequence Detail 62037 C57BL/6J ±  kb
    transcript NM_175441 RefSeq | MGI Sequence Detail 3070 C57BL/6  
    polypeptide Q3UIZ8 UniProt | EBI | MGI Sequence Detail 795 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 1
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 43
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:287274 Williams JL, et al., Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not. Life Sci Alliance. 2020 Apr;3(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory