About   Help   FAQ
Sun2 Gene Detail
Summary
  • Symbol
    Sun2
  • Name
    Sad1 and UNC84 domain containing 2
  • Synonyms
    B230369L08Rik, Unc84b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443011
    NCBI Gene: 223697
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79608271-79626737 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443011
 protein coding gene Chr15:79608269-79626757 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022084
 protein coding gene Chr15:80017866-80035600 (-)
A/J MGP_AJ_G0022045
 protein coding gene Chr15:77248575-77266421 (-)
AKR/J MGP_AKRJ_G0022020
 protein coding gene Chr15:79411246-79429092 (-)
BALB/cJ MGP_BALBcJ_G0022051
 protein coding gene Chr15:77261238-77279976 (-)
C3H/HeJ MGP_C3HHeJ_G0021822
 protein coding gene Chr15:79397402-79416504 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022494
 protein coding gene Chr15:83166682-83185768 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020024
 protein coding gene Chr15:73731118-73749246 (-)
CAST/EiJ MGP_CASTEiJ_G0021343
 protein coding gene Chr15:80110108-80127913 (-)
CBA/J MGP_CBAJ_G0021787
 protein coding gene Chr15:85755963-85778131 (-)
DBA/2J MGP_DBA2J_G0021916
 protein coding gene Chr15:76735418-76753316 (-)
FVB/NJ MGP_FVBNJ_G0021894
 protein coding gene Chr15:75763237-75781951 (-)
LP/J MGP_LPJ_G0021984
 protein coding gene Chr15:80206281-80227453 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021914
 protein coding gene Chr15:90855714-90875015 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022508
 protein coding gene Chr15:79431817-79450697 (-)
PWK/PhJ MGP_PWKPhJ_G0021085
 protein coding gene Chr15:76746402-76764779 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020922
 protein coding gene Chr15:79229752-79251070 (-)
WSB/EiJ MGP_WSBEiJ_G0021395
 protein coding gene Chr15:79816311-79835136 (-)



Homology
more
  • Human Ortholog
    SUN2, Sad1 and UNC84 domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUN2, Sad1 and UNC84 domain containing 2
  • Synonyms
    rab5IP, UNC84B
  • Links
    NCBI Gene ID: 25777
    neXtProt AC: NX_Q9UH99
    UniProt: Q9UH99

  • Chr Location
    22q13.1; chr22:38733290-38794143 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit no gross abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    45
  • cDNA Data
    65
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042524 Ensembl Gene Model | MGI Sequence Detail 18467 C57BL/6J ±  kb
    transcript ENSMUST00000046259 Ensembl | MGI Sequence Detail 3804 Not Applicable  
    polypeptide ENSMUSP00000047864 Ensembl | MGI Sequence Detail 731 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 65
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146038
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 14
      Phenotypes 43
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:341625 Jiao S, et al., SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness. Nat Commun. 2023 Oct 12;14(1):6416
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory