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Dars2 Gene Detail
Summary
  • Symbol
    Dars2
  • Name
    aspartyl-tRNA synthetase 2 (mitochondrial)
  • Synonyms
    5830468K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442510
    NCBI Gene: 226539
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:160868171-160898228 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 69.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442510
protein coding gene Chr1:160868171-160898236 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016647
protein coding gene Chr1:166291372-166325290 (-)
A/J MGP_AJ_G0016628
protein coding gene Chr1:159524831-159555537 (-)
AKR/J MGP_AKRJ_G0016594
protein coding gene Chr1:164392375-164423550 (-)
BALB/cJ MGP_BALBcJ_G0016589
protein coding gene Chr1:160065459-160096138 (-)
C3H/HeJ MGP_C3HHeJ_G0016413
protein coding gene Chr1:164593234-164623057 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017050
protein coding gene Chr1:171938188-171971185 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014759
protein coding gene Chr1:151641790-151673424 (-)
CAST/EiJ MGP_CASTEiJ_G0015993
protein coding gene Chr1:164203368-164237148 (-)
CBA/J MGP_CBAJ_G0016388
protein coding gene Chr1:178019720-178060508 (-)
DBA/2J MGP_DBA2J_G0016494
protein coding gene Chr1:158503179-158533523 (-)
FVB/NJ MGP_FVBNJ_G0016492
protein coding gene Chr1:156912927-156943614 (-)
LP/J MGP_LPJ_G0016565
protein coding gene Chr1:167381187-167412470 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016517
protein coding gene Chr1:185593536-185623510 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017086
protein coding gene Chr1:164211076-164241062 (-)
PWK/PhJ MGP_PWKPhJ_G0015779
protein coding gene Chr1:157659266-157690077 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015566
protein coding gene Chr1:163106117-163140515 (-)
WSB/EiJ MGP_WSBEiJ_G0016055
protein coding gene Chr1:164401853-164432967 (-)



Homology
more
  • Human Ortholog
    DARS2, aspartyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DARS2, aspartyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    ASPRS, LBSL, mtAspRS, MT-ASPRS
  • Links
    NCBI Gene ID: 55157
    neXtProt AC: NX_Q6PI48
    UniProt: Q6PI48

  • Chr Location
    1q25.1; chr1:173824653-173858808 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026709 Ensembl Gene Model | MGI Sequence Detail 30058 C57BL/6J ±  kb
    transcript ENSMUST00000035430 Ensembl | MGI Sequence Detail 3619 Not Applicable  
    polypeptide ENSMUSP00000041851 Ensembl | MGI Sequence Detail 653 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006282 aspartate--tRNA ligase, mitochondrial
    • EC
    • InterPro Domains
      IPR006195 Aminoacyl-tRNA synthetase, class II
      IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
      IPR004524 Aspartate-tRNA ligase, type 1
      IPR047089 Aspartate-tRNA ligase, type 1, anticodon recognition domain
      IPR047090 Aspartate-tRNA ligase, type 1, core domain
      IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
      IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
      IPR029351 GAD domain
      IPR004115 GAD-like domain superfamily
      IPR012340 Nucleic acid-binding, OB-fold
      IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 66

      Microarray probesets 2
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:327265 Croon M, et al., FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction. Sci Adv. 2022 Apr 8;8(14):eabn7105

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory