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Dusp4 Gene Detail
Summary
  • Symbol
    Dusp4
  • Name
    dual specificity phosphatase 4
  • Synonyms
    2700078F24Rik, E130306H24Rik, MKP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442191
    NCBI Gene: 319520
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:35274451-35287048 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 21.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442191
 protein coding gene Chr8:35274448-35289106 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033535
 protein coding gene Chr8:33360084-33372643 (+)
A/J MGP_AJ_G0033515
 protein coding gene Chr8:32026035-32038578 (+)
AKR/J MGP_AKRJ_G0033439
 protein coding gene Chr8:33036857-33049443 (+)
BALB/cJ MGP_BALBcJ_G0033511
 protein coding gene Chr8:32145555-32158116 (+)
C3H/HeJ MGP_C3HHeJ_G0033223
 protein coding gene Chr8:33372148-33385407 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034027
 protein coding gene Chr8:34640937-34653507 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030976
 protein coding gene Chr8:29019976-29033006 (+)
CAST/EiJ MGP_CASTEiJ_G0032550
 protein coding gene Chr8:32844332-32856854 (+)
CBA/J MGP_CBAJ_G0033201
 protein coding gene Chr8:35954317-35966867 (+)
DBA/2J MGP_DBA2J_G0033354
 protein coding gene Chr8:31995542-32008123 (+)
FVB/NJ MGP_FVBNJ_G0033299
 protein coding gene Chr8:31664324-31676919 (+)
LP/J MGP_LPJ_G0033444
 protein coding gene Chr8:33328051-33340553 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033341
 protein coding gene Chr8:35459744-35472292 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034046
 protein coding gene Chr8:33132281-33144876 (+)
PWK/PhJ MGP_PWKPhJ_G0032261
 protein coding gene Chr8:31546166-31559495 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032092
 protein coding gene Chr8:32402472-32415105 (+)
WSB/EiJ MGP_WSBEiJ_G0032666
 protein coding gene Chr8:33302559-33315412 (+)



Homology
more
  • Human Ortholog
    DUSP4, dual specificity phosphatase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DUSP4, dual specificity phosphatase 4
  • Synonyms
    HVH2, MKP2, MKP-2, TYP
  • Links
    NCBI Gene ID: 1846
    neXtProt AC: NX_Q13115
    UniProt: Q13115

  • Chr Location
    8p12; chr8:29333064-29350684 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 4 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a decrease in B cell apoptosis of bone marrow-derived, IL-7-dependent pro-B lymphocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    830
  • Tissues
    62
  • cDNA Data
    9
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031530 Ensembl Gene Model | MGI Sequence Detail 12598 C57BL/6J ±  kb
    transcript ENSMUST00000033930 Ensembl | MGI Sequence Detail 2740 Not Applicable  
    polypeptide ENSMUSP00000033930 Ensembl | MGI Sequence Detail 398 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917486, MGI:2142625, MGI:2142829
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 21
      Gene Ontology 6
      Phenotypes 30
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:338938 Kobayashi K, et al., Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15 axis is essential for fetal growth. Life Sci Alliance. 2023 Oct;6(10)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory