Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc4a1tm1Ahc
Name:	solute carrier family 4 (anion exchanger), member 1; targeted mutation 1, Athar H Chishti
MGI ID:	MGI:2441657
Synonyms:	band 3-/-
Gene:	Slc4a1  Location: Chr11:102239646-102256107 bp, - strand  Genetic Position: Chr11, 66.29 cM, cytoband D
Alliance:	Slc4a1tm1Ahc page

Germline Transmission:	Earliest citation of germline transmission: J:35637
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette was inserted into exon 3. The insertion disrupted the coding region 12 codons downstream of the erythroid-specific start codon. While no protein was detected in red blood cells obtained from homozygous mutant mice, translation of the kidney specific isoform, which is initiated from a start codon downstream of the inserted neo cassette, was verified by Western blot analysis of kidney lysates. (J:35637)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc4a1 Mutation:	54 strains or lines available

Original:	J:35637 Southgate CD, et al., Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton. Nat Genet. 1996 Oct;14(2):227-30
All:	4 reference(s)