Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ccnb2tm1Thnt
Name:	cyclin B2; targeted mutation 1, Tim Hunt
MGI ID:	MGI:2429974
Gene:	Ccnb2  Location: Chr9:70314974-70328829 bp, - strand  Genetic Position: Chr9, 39.53 cM, cytoband D
Alliance:	Ccnb2tm1Thnt page

Germline Transmission:	Earliest citation of germline transmission: J:47430
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 and 5 were replaced with a neomycin selection cassette. The deleted sequence encoded the conserved cyclin box involved in the binding of cell cycle division 2. While neither mRNA nor protein was detected in homozygous mutant mice by Northern and Western blot analyses, 5' and amino terminal fragments were expected in vivo. (J:47430)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccnb2 Mutation:	31 strains or lines available

Original:	J:47430 Brandeis M, et al., Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4344-9
All:	4 reference(s)