Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pou3f2tm1Tno
Name:	POU domain, class 3, transcription factor 2; targeted mutation 1, Tetsuo Noda
MGI ID:	MGI:2429695
Synonyms:	Brn-2DeltaC
Gene:	Pou3f2  Location: Chr4:22482780-22488366 bp, - strand  Genetic Position: Chr4, 9.73 cM
Alliance:	Pou3f2tm1Tno page

Germline Transmission:	Earliest citation of germline transmission: J:30429
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3' portion of the endogenous gene encoding both the POU specific and POU homeo domains was replaced by a PGK-neo cassette inserted by homologous recombination. The loss of octamer binding activity in homozygous mutant mice was demonstrated with electrophoresis mobility shift assays. (J:30429)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou3f2 Mutation:	19 strains or lines available

Original:	J:30429 Nakai S, et al., The POU domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse. Genes Dev. 1995 Dec 15;9(24):3109-21
All:	3 reference(s)