Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Asic3tm1Wsh
Name:	acid-sensing ion channel 3; targeted mutation 1, Michael J Welsh
MGI ID:	MGI:2429689
Synonyms:	ASIC3-, DRASIC-
Gene:	Asic3  Location: Chr5:24618449-24622836 bp, + strand  Genetic Position: Chr5, 11.72 cM
Alliance:	Asic3tm1Wsh page

Germline Transmission:	Earliest citation of germline transmission: J:73505
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with a floxed neomycin selection cassette inserted by homologous recombination. The deleted region contained the translational start codon and encoded the transmembrane domain and a portion of the extracellular domain. Transcript was undetected in homozygous mutant mice by RT-PCR analysis. (J:73505)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Asic3 Mutation:	29 strains or lines available

Original:	J:73505 Price MP, et al., The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice. Neuron. 2001 Dec 20;32(6):1071-83
All:	20 reference(s)