Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cabin1tm1Che
Name:	calcineurin binding protein 1; targeted mutation 1, Jianzhu Chen
MGI ID:	MGI:2429669
Synonyms:	Cabin1-neo
Gene:	Cabin1  Location: Chr10:75481946-75600175 bp, - strand  Genetic Position: Chr10, 38.56 cM
Alliance:	Cabin1tm1Che page

Germline Transmission:	Earliest citation of germline transmission: J:72760
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The last two exons of the endogenous gene were replaced by a floxed neo cassette inserted by homologous recombination. The deleted region encoded the carboxy terminal which includes calcineurin, calmodulin, and MEF2 binding domains. (J:72760)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cabin1 Mutation:	113 strains or lines available

Original:	J:72760 Esau C, et al., Deletion of Calcineurin and Myocyte Enhancer Factor 2 (MEF2) Binding Domain of Cabin1 Results in Enhanced Cytokine Gene Expression in T Cells. J Exp Med. 2001 Nov 19;194(10):1449-59
All:	1 reference(s)