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Irak2 Gene Detail
Summary
  • Symbol
    Irak2
  • Name
    interleukin-1 receptor-associated kinase 2
  • Synonyms
    6330415L08Rik, IRAK-2, Irak2a, Irak2b, Irak2c, Irak2d
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429603
    NCBI Gene: 108960
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113615428-113671987 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.82 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    479 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429603
 protein coding gene Chr6:113615428-113671987 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031134
 protein coding gene Chr6:116177572-116239750 (+)
A/J MGP_AJ_G0031103
 protein coding gene Chr6:111717395-111775226 (+)
AKR/J MGP_AKRJ_G0031034
 protein coding gene Chr6:114718203-114779949 (+)
BALB/cJ MGP_BALBcJ_G0031114
 protein coding gene Chr6:111663189-111720623 (+)
C3H/HeJ MGP_C3HHeJ_G0030594
 protein coding gene Chr6:69517467-69580646 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031573
 protein coding gene Chr6:119169388-119236237 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028737
 protein coding gene Chr6:108743266-108800840 (+)
CAST/EiJ MGP_CASTEiJ_G0030221
 protein coding gene Chr6:115176299-115237443 (+)
CBA/J MGP_CBAJ_G0030800
 protein coding gene Chr6:123881510-123946141 (+)
DBA/2J MGP_DBA2J_G0030953
 protein coding gene Chr6:110798915-110855542 (+)
FVB/NJ MGP_FVBNJ_G0030907
 protein coding gene Chr6:109802279-109859729 (+)
LP/J MGP_LPJ_G0031033
 protein coding gene Chr6:116202661-116264060 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030941
 protein coding gene Chr6:128134885-128194291 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031600
 protein coding gene Chr6:114735117-114798381 (+)
PWK/PhJ MGP_PWKPhJ_G0029937
 protein coding gene Chr6:109753252-109817351 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029765
 protein coding gene Chr6:113543535-113604449 (+)
WSB/EiJ MGP_WSBEiJ_G0030305
 protein coding gene Chr6:115113281-115174313 (+)



Homology
more
  • Human Ortholog
    IRAK2, interleukin 1 receptor associated kinase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRAK2, interleukin 1 receptor associated kinase 2
  • Synonyms
    IRAK-2
  • Links
    NCBI Gene ID: 3656
    neXtProt AC: NX_O43187
    UniProt: O43187

  • Chr Location
    3p25.3; chr3:10164919-10243745 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased susceptibility to endotoxin shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    24
  • cDNA Data
    24
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108960 NCBI Gene Model | MGI Sequence Detail 56560 C57BL/6J ±  kb
    transcript NM_172161 RefSeq | MGI Sequence Detail 3209 ZRU/MplStud  
    polypeptide Q8CFA1 UniProt | EBI | MGI Sequence Detail 622 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1922037, MGI:2141461
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 24
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory