Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mostm1Sia
Name:	Moloney sarcoma oncogene; targeted mutation 1, Shinichi Aizawa
MGI ID:	MGI:2429547
Gene:	Mos  Location: Chr4:3870658-3872105 bp, - strand  Genetic Position: Chr4, 2.16 cM, cytoband A1-A2
Alliance:	Mostm1Sia page

Germline Transmission:	Earliest citation of germline transmission: J:19086
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The endogenous allele was disrupted by the insertion of a PGK-neo cassette into sequences encoding kinase domain 5. RNAse protection showed a 214 bp 5' fragment as well as a 3' fragment expressed from the PGK promoter. Stop codons in the neo cassette preclude the translation of 3' kinase domains. (J:19086)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mos Mutation:	21 strains or lines available

Original:	J:19086 Hashimoto N, et al., Parthenogenetic activation of oocytes in c-mos-deficient mice [see comments] [published erratum appears in Nature 1994 Aug 4;370(6488):391]. Nature. 1994 Jul 7;370(6484):68-71
All:	2 reference(s)