Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	M6prtm1Psa
Name:	mannose-6-phosphate receptor, cation dependent; targeted mutation 1, Paul Saftig
MGI ID:	MGI:2429535
Synonyms:	MPR46 -
Gene:	M6pr  Location: Chr6:122285679-122294639 bp, + strand  Genetic Position: Chr6, 57.52 cM
Alliance:	M6prtm1Psa page

Germline Transmission:	Earliest citation of germline transmission: J:16151
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 3 was disrupted by the insertion of a neomycin selection cassette. Expression was undetected by Northern and Western blot analysis various tissues obtained from homozygous mutant mice. (J:16151)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any M6pr Mutation:	25 strains or lines available

Original:	J:16151 Koster A, et al., Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins. EMBO J. 1993 Dec 15;12(13):5219-23
All:	8 reference(s)