Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Sncatm1Nbm
Name:	synuclein, alpha; targeted mutation 1, Robert L Nussbaum
MGI ID:	MGI:2389489
Synonyms:	Scna-, Snca-
Gene:	Snca  Location: Chr6:60708559-60806839 bp, - strand  Genetic Position: Chr6, 29.15 cM
Alliance:	Sncatm1Nbm page

Germline Transmission:	Earliest citation of germline transmission: J:79784
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 and 5 were replaced with a neomycin selection cassette inserted by homologous recombination. While the separation of Western blot results by 2D-PAGE showed various isoforms in total brain extract obtained from wild-type mice, protein was undetected in samples obtained from homozygous mutant mice. (J:79784)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Snca Mutation:	34 strains or lines available

Original:	J:79784 Cabin DE, et al., Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci. 2002 Oct 15;22(20):8797-807
All:	25 reference(s)