Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dpep1tm1Mwl
Name:	dipeptidase 1; targeted mutation 1, Michael W Lieberman
MGI ID:	MGI:2389068
Synonyms:	MBD-, MBDm1
Gene:	Dpep1  Location: Chr8:123913069-123928551 bp, + strand  Genetic Position: Chr8, 72.08 cM
Alliance:	Dpep1tm1Mwl page

Germline Transmission:	Earliest citation of germline transmission: J:47610
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exon 1 and flanking sequences with a PGK-Hprt cassette via homologous recombination. The gene targeting event results in deletion of a splice acceptor site necessary for processing different protein isoforms, a 16 amino acid signal sequence, and 18 amino acids of the mature protein. Northern blot analysis of various tissues from homozygous mutant animals using a 620 bp cDNA probe did not detect gene expression. (J:47610)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dpep1 Mutation:	25 strains or lines available

Original:	J:47610 Habib GM, et al., Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4859-63
All:	2 reference(s)