Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Canxtm1Den
Name:	calnexin; targeted mutation 1, Angela Denzel
MGI ID:	MGI:2388893
Synonyms:	cnx-
Gene:	Canx  Location: Chr11:50184788-50216500 bp, - strand  Genetic Position: Chr11, 30.46 cM
Alliance:	Canxtm1Den page

Germline Transmission:	Earliest citation of germline transmission: J:79604
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A fragment encompassing 137 bp of exon 4, intron 4, and all of exon 5 was replaced with a floxed selection cassette. Protein was undetected in homozygous mutant mice by Western blot analysis using amino- and carboxyl-terminal antibodies. (J:79604)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Canx Mutation:	54 strains or lines available

Original:	J:79604 Denzel A, et al., Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression. Mol Cell Biol. 2002 Nov;22(21):7398-404
All:	2 reference(s)