Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Elf4tm1Nim
Name:	E74 like ETS transcription factor 4; targeted mutation 1, Stephen D Nimer
MGI ID:	MGI:2388892
Synonyms:	MEF-
Gene:	Elf4  Location: ChrX:47499926-47552009 bp, - strand  Genetic Position: ChrX, 25.67 cM, cytoband A3.2
Alliance:	Elf4tm1Nim page

Germline Transmission:	Earliest citation of germline transmission: J:79568
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The majority of the coding region including the ETS domain was replaced by a neomycin selection cassette inserted by homologous recombination. RT-PCR analysis of bone marrow cells isolated from homozygous mutant (female) mice showed a lack of transcript. The absence of protein was demonstrated by Western blot analysis of thymic lysates. (J:79568)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Elf4 Mutation:	17 strains or lines available

Original:	J:79568 Lacorazza HD, et al., The ETS Protein MEF Plays a Critical Role in Perforin Gene Expression and the Development of Natural Killer and NK-T Cells. Immunity. 2002 Oct;17(4):437
All:	17 reference(s)