Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Map3k8tm1Pnt
Name:	mitogen-activated protein kinase kinase kinase 8; targeted mutation 1, Phillip Tsichlis
MGI ID:	MGI:2388714
Synonyms:	Map3k8tm1Ceci, Tpl2 -
Gene:	Map3k8  Location: Chr18:4331325-4352978 bp, - strand  Genetic Position: Chr18, 2.73 cM
Alliance:	Map3k8tm1Pnt page

Germline Transmission:	Earliest citation of germline transmission: J:66503
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence extending from within exon 3 to within exon 5 was replaced by a neomycin selection cassette. The deleted region encoded a portion of the catalytic domain including ATP binding site and the activation loop. Transcript was detected by Northern blot analysis of homozygous mutant splenocytes. (J:66503)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k8 Mutation:	41 strains or lines available

Original:	J:66503 Dumitru CD, et al., TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell. 2000 Dec 22;103(7):1071-83
All:	51 reference(s)