Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gpx1tm1Kola
Name:	glutathione peroxidase 1; targeted mutation 1, Ismail Kola
MGI ID:	MGI:2388705
Synonyms:	Gpx1-
Gene:	Gpx1  Location: Chr9:108216279-108217541 bp, + strand  Genetic Position: Chr9, 59.24 cM, cytoband F1
Alliance:	Gpx1tm1Kola page

Germline Transmission:	Earliest citation of germline transmission: J:49644
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 1 via homologous recombination. Northern blot analysis failed to detect gene expression in any of the tissues examined from homozygous mutant animals (brain, heart, kidney, liver, and lung). (J:49644)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gpx1 Mutation:	19 strains or lines available

Original:	J:49644 de Haan JB, et al., Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide. J Biol Chem. 1998 Aug 28;273(35):22528-36
All:	23 reference(s)