Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxd3tm2Mrc
Name:	homeobox D3; targeted mutation 2, Mario R Capecchi
MGI ID:	MGI:2388512
Synonyms:	Hoxd3-, Hoxd3null
Gene:	Hoxd3  Location: Chr2:74542337-74578615 bp, + strand  Genetic Position: Chr2, 44.13 cM, cytoband C2
Alliance:	Hoxd3tm2Mrc page

Germline Transmission:	Earliest citation of germline transmission: J:60296
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by insertion of a self-excising neomycin resistance cassette into exon 2. Following removal of the neo cassette, 249 bp of endogenous exon 2 sequences were replaced with a single loxP site. (J:60296)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd3 Mutation:	13 strains or lines available

Original:	J:60296 Greer JM, et al., Maintenance of functional equivalence during paralogous Hox gene evolution [see comments]. Nature. 2000 Feb 10;403(6770):661-5
All:	2 reference(s)