Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Folh1tm1Nle
Name:	folate hydrolase 1; targeted mutation 1, Joseph H Neale
MGI ID:	MGI:2388359
Synonyms:	Folh1-, Folh1tm1ski, PMSA-
Gene:	Folh1  Location: Chr7:86368185-86425151 bp, - strand  Genetic Position: Chr7, 48.51 cM, cytoband D1-D2
Alliance:	Folh1tm1Nle page

Germline Transmission:	Earliest citation of germline transmission: J:79368
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The endogenous locus was disrupted by the insertion of a vector that replaced the 3' and 5' splice sites of exons 1 and 2, respectively, with sequence containing stop codons. The targeting vector also included a neo cassette that replaced the majority of intron 1. Neither transcript nor protein was detected by Northern or Western blot analyses of brain tissue obtained from homozygous mutant mice. (J:79368)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Folh1 Mutation:	50 strains or lines available

Original:	J:79368 Bacich DJ, et al., Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate. J Neurochem. 2002 Oct;83(1):20-9
All:	5 reference(s)