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Gfi1btm1Sho
Targeted Allele Detail
Summary
Symbol: Gfi1btm1Sho
Name: growth factor independent 1B; targeted mutation 1, Stuart Orkin
MGI ID: MGI:2388162
Synonyms: Gfi-1b-, Gfi-1b-/-(neoR+)
Gene: Gfi1b  Location: Chr2:28499462-28511994 bp, - strand  Genetic Position: Chr2, 19.38 cM
Alliance: Gfi1btm1Sho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74523
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 4 were replaced with a floxed neomycin selection cassette inserted by homologous recombination. The deleted region included the translational start codon. (J:74523)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gfi1b Mutation:  20 strains or lines available
References
Original:  J:74523 Saleque S, et al., The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Genes Dev. 2002 Feb 1;16(3):301-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory