Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Amphtm1Pdc
Name:	amphiphysin; targeted mutation 1, Pietro De Camilli
MGI ID:	MGI:2388118
Gene:	Amph  Location: Chr13:19132375-19335091 bp, + strand  Genetic Position: Chr13, 6.89 cM
Alliance:	Amphtm1Pdc page

Germline Transmission:	Earliest citation of germline transmission: J:75306
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was disrupted by the insertion of a neomycin selection cassette. Protein was undetected by Western blot analysis and immunofluorescence staining. (J:75306)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Amph Mutation:	51 strains or lines available

Original:	J:75306 Di Paolo G, et al., Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Neuron. 2002 Feb 28;33(5):789-804
All:	4 reference(s)