Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sstr2tm1Rgs
Name:	somatostatin receptor 2; targeted mutation 1, Roy G Smith
MGI ID:	MGI:2388099
Synonyms:	sst2-, SSTR2-
Gene:	Sstr2  Location: Chr11:113510168-113516854 bp, + strand  Genetic Position: Chr11, 79.05 cM
Alliance:	Sstr2tm1Rgs page

Germline Transmission:	Earliest citation of germline transmission: J:43192
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 1.2 kb of coding region was deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Northern blot analysis of brain RNA from homozygous mutant animals using a full-length cDNA probe. (J:43192)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sstr2 Mutation:	32 strains or lines available

Original:	J:43192 Zheng H, et al., Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. Mol Endocrinol. 1997 Oct;11(11):1709-17
All:	19 reference(s)