Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ssttm1Low
Name:	somatostatin; targeted mutation 1, Malcolm J Low
MGI ID:	MGI:2388093
Synonyms:	Smst-
Gene:	Sst  Location: Chr16:23708323-23709708 bp, - strand  Genetic Position: Chr16, 15.0 cM, cytoband cen-C3
Alliance:	Ssttm1Low page

Germline Transmission:	Earliest citation of germline transmission: J:70016
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of the promoter region and exon 1 with a PGK-neo cassette. Radioimmunoassay was unable to detect protein product from stomach and brain extracts from homozygous mutant animals. (J:70016)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sst Mutation:	35 strains or lines available

Original:	J:70016 Low MJ, et al., Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth. J Clin Invest. 2001 Jun;107(12):1571-80
All:	10 reference(s)