Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Smarca2tm1Mya
Name:	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; targeted mutation 1, Moshe Yaniv
MGI ID:	MGI:2387988
Synonyms:	BRM-
Gene:	Smarca2  Location: Chr19:26582578-26755721 bp, + strand  Genetic Position: Chr19, 21.17 cM, cytoband C1
Alliance:	Smarca2tm1Mya page

Germline Transmission:	Earliest citation of germline transmission: J:51536
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The majority of the exon encoding amino acids 120-176 was replaced with a neomycin resistance cassette via homologous recombination. RT-PCR analysis of liver RNA from homozygous mutant animals revealed a faint truncated transcript resulting from an alternative splice product which skips the disrupted exon. Western blot analysis of brain nuclear extracts detected a shortened protein product expressed at less than 1% the amount of wild-type protein. Co-immunoprecipitation experiments showed that the mutant protein lacked functional capabilities. (J:51536)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	64 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

List all tumor models in MMHCdb carrying Smarca2tm1Mya

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smarca2 Mutation:	90 strains or lines available

Original:	J:51536 Reyes JC, et al., Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha). EMBO J. 1998 Dec 1;17(23):6979-91
All:	18 reference(s)