Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mslntm1Ipa
Name:	mesothelin; targeted mutation 1, Ira Pastan
MGI ID:	MGI:2387955
Synonyms:	Meso -
Gene:	Msln  Location: Chr17:25967587-25973352 bp, - strand  Genetic Position: Chr17, 12.85 cM, cytoband A3.3
Alliance:	Mslntm1Ipa page

Germline Transmission:	Earliest citation of germline transmission: J:61336
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of sequences spanning exon 1 to intron 3 with a neomycin resistance cassette. The mutation deletes amino acids 20-100. Northern blot and RT-PCR analysis of lung samples from homozygous mutant animals did not detect gene expression. In situ hybridization of various tissues from homozygous animals using antibodies against the protein confirmed the null allele. (J:61336)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

6 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msln Mutation:	36 strains or lines available

Original:	J:61336 Bera TK, et al., Mesothelin is not required for normal mouse development or reproduction. Mol Cell Biol. 2000 Apr;20(8):2902-6
All:	5 reference(s)