Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Pou3f1tm2Mejr
Name:	POU domain, class 3, transcription factor 1; targeted mutation 2, Dies Meijer
MGI ID:	MGI:2387951
Synonyms:	Oct-6Puro
Gene:	Pou3f1  Location: Chr4:124551439-124554448 bp, + strand  Genetic Position: Chr4, 57.86 cM
Alliance:	Pou3f1tm2Mejr page

Germline Transmission:	Earliest citation of germline transmission: J:78939
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Modified regulatory region, Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A Schwann cell specific knockout was generated by replacing a 4.3 kb Schwann cell specific enhancer element downstream of the coding region with a floxed puromycin selection cassette. Mice carrying this allele were used to generate Pou3f1tm2.1Mejr. (J:78939)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou3f1 Mutation:	14 strains or lines available

Original:	J:78939 Ghazvini M, et al., A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration. EMBO J. 2002 Sep 2;21(17):4612-20
All:	1 reference(s)