Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Msh2tm1Whl
Name:	mutS homolog 2; targeted mutation 1, Wen-Hwa Lee
MGI ID:	MGI:2387935
Synonyms:	Msh2-
Gene:	Msh2  Location: Chr17:87979960-88031141 bp, + strand  Genetic Position: Chr17, 57.87 cM
Alliance:	Msh2tm1Whl page

Germline Transmission:	Earliest citation of germline transmission: J:79016
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3' portion of exon 3 was replaced by a neomycin selection cassette inserted by homologous recombination. (J:79016)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Msh2tm1Whl

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msh2 Mutation:	95 strains or lines available

Original:	J:79016 Nikitin AY, et al., Cell Lineage-specific Effects Associated with Multiple Deficiencies of Tumor Susceptibility Genes in Msh2(-/-)Rb(+/-) Mice. Cancer Res. 2002 Sep 15;62(18):5134-8
All:	2 reference(s)