Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mmp11tm1Mrio
Name:	matrix metallopeptidase 11; targeted mutation 1, Marie-Christine Rio
MGI ID:	MGI:2387934
Synonyms:	ST3-
Gene:	Mmp11  Location: Chr10:75759056-75768336 bp, - strand  Genetic Position: Chr10, 38.62 cM
Alliance:	Mmp11tm1Mrio page

Germline Transmission:	Earliest citation of germline transmission: J:79012
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: All of exons 2 through 6 and 5' portion of exon 7 were replaced by a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of RNA isolated from involuting uteri of homozygous mutant mice. (J:79012)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

7 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp11 Mutation:	34 strains or lines available

Original:	J:79012 Masson R, et al., In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy. J Cell Biol. 1998 Mar 23;140(6):1535-41
All:	7 reference(s)