About   Help   FAQ
Oprd1tm1Jep
Targeted Allele Detail
Summary
Symbol: Oprd1tm1Jep
Name: opioid receptor, delta 1; targeted mutation 1, John E Pintar
MGI ID: MGI:2387891
Synonyms: DOR-1 KO, DOR-KO
Gene: Oprd1  Location: Chr4:131838037-131871797 bp, - strand  Genetic Position: Chr4, 64.78 cM, cytoband D1-D3
Alliance: Oprd1tm1Jep page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57886
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced by a neomycin selection cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice using an antiserum directed against the amino terminal. Furthermore, an absence of ligand binding was determined via autoradiographic analysis of radiolabeled ligands that preferentially bind to the pharmacologically defined receptors, delta1 and delta2. (J:57886)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oprd1 Mutation:  29 strains or lines available
References
Original:  J:57886 Zhu Y, et al., Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice. Neuron. 1999 Sep;24(1):243-52
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory