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Omptm1Flm
Targeted Allele Detail
Summary
Symbol: Omptm1Flm
Name: olfactory marker protein; targeted mutation 1, Frank L Margolis
MGI ID: MGI:2387862
Gene: Omp  Location: Chr7:97792566-97794654 bp, - strand  Genetic Position: Chr7, 53.59 cM
Alliance: Omptm1Flm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36149
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding region of the endogenous locus was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis of homozygous mutant mice showed an absence of protein in olfactory epithelium and olfactory bulbs. ELISA showed the protein level in heterozygous mice to be 40-50% of that in wild-type mice. (J:36149)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Omp Mutation:  27 strains or lines available
References
Original:  J:36149 Buiakova OI, et al., Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9858-63
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory