Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sod1tm1Dkd
Name:	superoxide dismutase 1, soluble; targeted mutation 1, Dipak K Das
MGI ID:	MGI:2387861
Synonyms:	Cu/ZnSOD-KO, Sod 1-
Gene:	Sod1  Location: Chr16:90017650-90023221 bp, + strand  Genetic Position: Chr16, 51.56 cM, cytoband B5-C3
Alliance:	Sod1tm1Dkd page

Germline Transmission:	Earliest citation of germline transmission: J:60470
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exon 5 and flanking intronic sequences with a neomycin resistance cassette via homologous recombination. The mutation deletes C-terminal amino acids 120-154 which constitute the structure and function of the active site channel. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of heart tissue. (J:60470)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sod1 Mutation:	37 strains or lines available

Original:	J:60470 Yoshida T, et al., Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury. Circ Res. 2000 Feb 18;86(3):264-9
All:	2 reference(s)